Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy

Long non-coding RNAs (lncRs), by virtue of their versatility and multilevel gene regulation, have emerged as attractive pharmacological targets for treating heterogenous and complex malignancies like triple-negative breast cancer (TNBC). Despite multiple studies on lncRNA functions in tumor patholog...

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Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Vaidya, Amita M, Sun, Zhanhu, Ayat, Nadia, Schilb, Andrew, Liu, Xujie, Jiang, Hongfa, Sun, Da, Scheidt, Josef, Qian, Victoria, He, Siyuan, Gilmore, Hannah, Schiemann, William P., Lu, Zheng-Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820053/
https://ncbi.nlm.nih.gov/pubmed/30739442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.9b00028
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