Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

IMPORTANCE: Corticolimbic patterns of neurofibrillary tangle (NFT) accumulation define neuropathologic subtypes of Alzheimer disease (AD), which underlie the clinical heterogeneity observed antemortem. The cholinergic system, which is the target of acetylcholinesterase inhibitor therapy, is selectiv...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Hanna Al-Shaikh, Fadi S., Duara, Ranjan, Crook, Julia E., Lesser, Elizabeth R., Schaeverbeke, Jolien, Hinkle, Kelly M., Ross, Owen A., Ertekin-Taner, Nilufer, Pedraza, Otto, Dickson, Dennis W., Graff-Radford, Neill R., Murray, Melissa E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820048/
https://ncbi.nlm.nih.gov/pubmed/31657834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.3606
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