Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

IMPORTANCE: Corticolimbic patterns of neurofibrillary tangle (NFT) accumulation define neuropathologic subtypes of Alzheimer disease (AD), which underlie the clinical heterogeneity observed antemortem. The cholinergic system, which is the target of acetylcholinesterase inhibitor therapy, is selectiv...

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Bibliographic Details
Published in:JAMA Neurol
Main Authors: Hanna Al-Shaikh, Fadi S., Duara, Ranjan, Crook, Julia E., Lesser, Elizabeth R., Schaeverbeke, Jolien, Hinkle, Kelly M., Ross, Owen A., Ertekin-Taner, Nilufer, Pedraza, Otto, Dickson, Dennis W., Graff-Radford, Neill R., Murray, Melissa E.
Format: Artigo
Language:Inglês
Published: American Medical Association 2019
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820048/
https://ncbi.nlm.nih.gov/pubmed/31657834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.3606
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