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Granzyme B Cleaves Multiple Herpes Simplex Virus 1 and Varicella-Zoster Virus (VZV) Gene Products, and VZV ORF4 Inhibits Natural Killer Cell Cytotoxicity

Immune regulation of alphaherpesvirus latency and reactivation is critical for the control of virus pathogenesis. This is evident for herpes simplex virus 1 (HSV-1), where cytotoxic T lymphocytes (CTLs) prevent viral reactivation independent of apoptosis induction. This inhibition of HSV-1 reactivat...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Gerada, Chelsea, Steain, Megan, Campbell, Tessa Mollie, McSharry, Brian, Slobedman, Barry, Abendroth, Allison
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819919/
https://ncbi.nlm.nih.gov/pubmed/31462576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01140-19
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