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Granzyme B Cleaves Multiple Herpes Simplex Virus 1 and Varicella-Zoster Virus (VZV) Gene Products, and VZV ORF4 Inhibits Natural Killer Cell Cytotoxicity

Immune regulation of alphaherpesvirus latency and reactivation is critical for the control of virus pathogenesis. This is evident for herpes simplex virus 1 (HSV-1), where cytotoxic T lymphocytes (CTLs) prevent viral reactivation independent of apoptosis induction. This inhibition of HSV-1 reactivat...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Gerada, Chelsea, Steain, Megan, Campbell, Tessa Mollie, McSharry, Brian, Slobedman, Barry, Abendroth, Allison
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819919/
https://ncbi.nlm.nih.gov/pubmed/31462576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01140-19
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