p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus

The Toll-like receptor 8 (TLR8) has an important role in innate immune responses to RNA viral infections, including respiratory syncytial virus (RSV). We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polym...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Menendez, Daniel, Snipe, Joyce, Marzec, Jacqui, Innes, Cynthia L., Polack, Fernando P., Caballero, Mauricio T., Schurman, Shepherd H., Kleeberger, Steven R., Resnick, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819090/
https://ncbi.nlm.nih.gov/pubmed/31430261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128626
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