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Endocrine Hormone Beta-estradiol and Anti-estrogen Letrozole Modulate 20:3 Isomer Production from 20:2n-6 in Human Cancer Cells (P08-119-19)

OBJECTIVES: The product of linoleic acid elongation, 20:2n-6, is the only known substrate for both FADS1 and FADS2. FADS1 catalyzes 20:2n-6 à 5Z,11Z,14Z-20:3 (sciadonic acid, SA), whereas FADS2 action yields 8Z,11Z,14Z-20:3 (DGLA). In certain cancer cell types, non-functional FADS2 activity unmasks...

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Detalhes bibliográficos
Publicado no:Curr Dev Nutr
Main Authors: Park, Hui Gyu, Kim, Jae Hun, Kothapalli, Kumar S D, Brenna, J Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818866/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzz044.P08-119-19
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