Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly

The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and bacteria. The obligate intracellular bacterial pathog...

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Vydáno v:PLoS Pathog
Hlavní autoři: Slade, Jessica A., Brockett, Mary, Singh, Raghuveer, Liechti, George W., Maurelli, Anthony T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818789/
https://ncbi.nlm.nih.gov/pubmed/31622442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008078
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