Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii

Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis. Apicomplexan parasites contain a relict chloroplast, the apicoplast. The apicoplast is indispensable and an attractive drug target. The apicoplast is home to a 1-deoxy-d-xylulose-5...

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Main Authors: Nair, Sethu C., Brooks, Carrie F., Goodman, Christopher D., Strurm, Angelika, McFadden, Geoffrey I., Sundriyal, Sandeep, Anglin, Justin L., Song, Yongcheng, Moreno, Silvia N.J., Striepen, Boris
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135366/
https://ncbi.nlm.nih.gov/pubmed/21690250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110039
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