Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki) mice to address this question. After tumor tr...

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Publié dans:Nat Commun
Auteurs principaux: Kusano, Teruo, Ehirchiou, Driss, Matsumura, Tomohiro, Chobaz, Veronique, Nasi, Sonia, Castelblanco, Mariela, So, Alexander, Lavanchy, Christine, Acha-Orbea, Hans, Nishino, Takeshi, Okamoto, Ken, Busso, Nathalie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817904/
https://ncbi.nlm.nih.gov/pubmed/31659168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12565-z
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