PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

PP2A holoenzyme complexes are responsible for the majority of Ser/Thr phosphatase activities in human cells. Each PP2A consists of a catalytic subunit (C), a scaffold subunit (A), and a regulatory subunit (B). While the A and C subunits each exists only in two highly conserved isoforms, a large numb...

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Udgivet i:Oncogenesis
Main Authors: Hein, Ashley L., Brandquist, Nichole D., Ouellette, Caroline Y., Seshacharyulu, Parthasarathy, Enke, Charles A., Ouellette, Michel M., Batra, Surinder K., Yan, Ying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817822/
https://ncbi.nlm.nih.gov/pubmed/31659153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0172-9
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