Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function

Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein kinase Cs (aPKCs). A planar cell polarity pro...

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Detaylı Bibliyografya
Yayımlandı:iScience
Asıl Yazarlar: Scott, John, Thakar, Sonal, Mao, Ye, Qin, Huaping, Hejran, Helen, Lee, Su-Yee, Yu, Ting, Klezovitch, Olga, Cheng, Hongqiang, Mu, Yongxin, Ghosh, Sourav, Vasioukhin, Valeri, Zou, Yimin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817635/
https://ncbi.nlm.nih.gov/pubmed/31546104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.005
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