A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data

To analyze family-based whole-genome sequence (WGS) data for complex traits, we developed a rare variant (RV) non-parametric linkage (NPL) analysis method, which has advantages over association methods. The RV-NPL differs from the NPL in that RVs are analyzed, and allele sharing among affected relat...

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Publicado en:Am J Hum Genet
Main Authors: Zhao, Linhai, He, Zongxiao, Zhang, Di, Wang, Gao T., Renton, Alan E., Vardarajan, Badri N., Nothnagel, Michael, Goate, Alison M., Mayeux, Richard, Leal, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817540/
https://ncbi.nlm.nih.gov/pubmed/31585107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.09.006
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