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Identifying Key Pathways and Components in Chemokine-Triggered T Lymphocyte Arrest Dynamics Using a Multi-Parametric Global Sensitivity Analysis

INTRODUCTION: The arrest of rolling T lymphocytes at specific locations is crucial to proper immune response function. We previously developed a model of chemokine-driven integrin activation, termed integrative signaling adhesive dynamics (ISAD). In addition, we have shown that loss of diacylglycero...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Bioeng
Autori principali: Lee, Dooyoung, Beste, Michael T., Anderson, Nicholas R., Koretzky, Gary A., Hammer, Daniel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816696/
https://ncbi.nlm.nih.gov/pubmed/31719909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12195-019-00575-2
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