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Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses
Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochond...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6816402/ https://ncbi.nlm.nih.gov/pubmed/31692879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1659078 |
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