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Telomere maintenance: regulating hTERC fate through RNA modifications

Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modification...

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Publicat a:Mol Cell Oncol
Autors principals: Lirussi, Lisa, Nilsen, Hilde
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816388/
https://ncbi.nlm.nih.gov/pubmed/31692866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1670489
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