Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow

Doxorubicin is a risk factor for secondary lymphedema in cancer patients exposed to surgery or radiation. The risk is presumed to relate to its cytotoxicity. However, the present study provides initial evidence that doxorubicin directly inhibits lymph flow and this action appears distinct from its c...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Stolarz, Amanda J., Sarimollaoglu, Mustafa, Marecki, John C., Fletcher, Terry W., Galanzha, Ekaterina I., Rhee, Sung W., Zharov, Vladimir P., Klimberg, V. Suzanne, Rusch, Nancy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815939/
https://ncbi.nlm.nih.gov/pubmed/31439806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.257592
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