K(ATP) Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema

Pharmacological openers of ATP-sensitive potassium (K(ATP)) channels are effective antihypertensive agents, but off-target effects, including severe peripheral edema, limit their clinical usefulness. It is presumed that the arterial dilation induced by K(ATP) channel openers (KCOs) increases capilla...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Garner, Brittney R., Stolarz, Amanda J., Stuckey, Daniel, Sarimollaoglu, Mustafa, Liu, Yunmeng, Palade, Philip T., Rusch, Nancy J., Mu, Shengyu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2021
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745085/
https://ncbi.nlm.nih.gov/pubmed/33100270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000121
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