Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs

In this study, we designed and validated a platform for ultrasound and microbubble-mediated delivery of FDA-approved pegylated poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with anticancer microRNAs (miRNAs) to deep tissues in a pig model. Small RNAs have been shown to reprogram tumor cel...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Ianni, Tommaso Di, Bose, Rajendran J.C., Sukumar, Uday K., Bachawal, Sunitha, Wang, Huaijun, Telichko, Arsenii, Herickhoff, Carl, Robinson, Elise, Baker, Sam, Vilches-Moure, José G., Felt, Stephen A., Gambhir, Sanjiv S., Paulmurugan, Ramasamy, Dahl, Jeremy D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815710/
https://ncbi.nlm.nih.gov/pubmed/31326463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.07.024
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