Thy1-Targeted Microbubbles for Ultrasound Molecular Imaging of Pancreatic Ductal Adenocarcinoma

PURPOSE: To engineer a dual human and murine Thy1-binding single-chain-antibody ligand (Thy1-scFv) for contrast microbubble-enhanced ultrasound molecular imaging of pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN: Thy1-scFv were engineered using yeast-surface-display techniques. Binding...

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Publicado no:Clin Cancer Res
Main Authors: Abou-Elkacem, Lotfi, Wang, Huaijun, Chowdhury, Sayan M., Kimura, Richard H., Bachawal, Sunitha V., Gambhir, Sanjiv S., Tian, Lu, Willmann, Jürgen K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884723/
https://ncbi.nlm.nih.gov/pubmed/29301827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2057
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