Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

AIMS: We investigated the changes of renal structure and its function in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in OLETF rats and explored the role of the INS/IRS-1/PI3-K/Akt signaling pathway. METHODS: OLETF...

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Bibliografski detalji
Izdano u:J Diabetes Res
Glavni autori: Zhang, Yi, Yang, Shaohua, Cui, Xiao, Yang, Juhong, Zheng, Miaoyan, Jia, Junya, Han, Fei, Yang, Xiaoyun, Wang, Jingyu, Guo, Zhenhong, Chang, Bai, Chang, Baocheng
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815570/
https://ncbi.nlm.nih.gov/pubmed/31737684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/4709715
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