Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway

AIMS: We investigated the changes of renal structure and its function in normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and diabetic kidney disease (DKD) stages in OLETF rats and explored the role of the INS/IRS-1/PI3-K/Akt signaling pathway. METHODS: OLETF...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Zhang, Yi, Yang, Shaohua, Cui, Xiao, Yang, Juhong, Zheng, Miaoyan, Jia, Junya, Han, Fei, Yang, Xiaoyun, Wang, Jingyu, Guo, Zhenhong, Chang, Bai, Chang, Baocheng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815570/
https://ncbi.nlm.nih.gov/pubmed/31737684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/4709715
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