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Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis

J-domain chaperones are involved in the efficient handover of misfolded/partially folded proteins to Hsp70 but also function independently to protect against cell death. Due to their high flexibility, the mechanism by which they regulate the Hsp70 cycle and how specific substrate recognition is perf...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Karamanos, Theodoros K., Tugarinov, Vitali, Clore, G. Marius
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815171/
https://ncbi.nlm.nih.gov/pubmed/31591220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914999116
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