Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

Meningiomas account for one-third of all primary brain tumors. Although typically benign, about 20% of meningiomas are aggressive, and despite the rigor of the current histopathological classification system there remains considerable uncertainty in predicting tumor behavior. Here, we analyzed 160 t...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Patel, Akash J., Wan, Ying-Wooi, Al-Ouran, Rami, Revelli, Jean-Pierre, Cardenas, Maria F., Oneissi, Mazen, Xi, Liu, Jalali, Ali, Magnotti, John F., Muzny, Donna M., Doddapaneni, HarshaVardhan, Sebastian, Sherly, Heck, Kent A., Goodman, J. Clay, Gopinath, Shankar P., Liu, Zhandong, Rao, Ganesh, Plon, Sharon E., Yoshor, Daniel, Wheeler, David A., Zoghbi, Huda Y., Klisch, Tiemo J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815170/
https://ncbi.nlm.nih.gov/pubmed/31591222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912858116
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