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Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

Treatment for medulloblastoma, the most common malignant brain tumor in children, remains limited to surgical resection, radiation, and traditional chemotherapy; with long-term survival as low as 50–60% for Sonic Hedgehog (Shh)-type medulloblastoma. We have shown that the transcription factor Atonal...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Klisch, Tiemo J, Vainshtein, Anna, Patel, Akash J, Zoghbi, Huda Y
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736349/
https://ncbi.nlm.nih.gov/pubmed/29168692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31181
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