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Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer

We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank. Among the disease conditions studied are Hypothy...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lello, Louis, Raben, Timothy G., Yong, Soke Yuen, Tellier, Laurent C. A. M., Hsu, Stephen D. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814833/
https://ncbi.nlm.nih.gov/pubmed/31653892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51258-x
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