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PU.1 and Epigenetic Signals Modulate 1,25-Dihydroxyvitamin D(3) and C/EBPα Regulation of the Human Cathelicidin Antimicrobial Peptide Gene in Lung Epithelial Cells

LL-37, the only known human cathelicidin which is encoded by the human antimicrobial peptide (CAMP) gene, plays a critical role in protection against bacterial infection. We previously demonstrated that cathelicidin is induced by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) in human airway epithelia...

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Détails bibliographiques
Publié dans:J Cell Physiol
Auteurs principaux: Wei, Ran, Dhawan, Puneet, Baiocchi, Robert A., Kim, Ki-Yoon, Christakos, Sylvia
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814306/
https://ncbi.nlm.nih.gov/pubmed/30387140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27702
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