Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: “next-day” gene therapy versus standard “two step” approach

Traditionally, ex vivo gene therapy involves a two-step approach, with culture expansion of cells prior to transduction and implantation. We have tried to simplify this strategy and eliminate the time and cost associated with culture expansion, by introducing “next-day” regional gene therapy using h...

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Bibliographic Details
Published in:	Bone
Main Authors:	Bougioukli, Sofia, Alluri, Ram, Pannell, William, Sugiyama, Osamu, Vega, Andrew, Tang, Amy, Skorka, Tautis, Park, Sang Hyun, Oakes, Daniel, Lieberman, Jay R.
Format:	Artigo
Language:	Inglês
Published:	2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6813891/ https://ncbi.nlm.nih.gov/pubmed/31398502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.08.005
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Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: “next-day” gene therapy versus standard “two step” approach

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