Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: “next-day” gene therapy versus standard “two step” approach

Traditionally, ex vivo gene therapy involves a two-step approach, with culture expansion of cells prior to transduction and implantation. We have tried to simplify this strategy and eliminate the time and cost associated with culture expansion, by introducing “next-day” regional gene therapy using h...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Bougioukli, Sofia, Alluri, Ram, Pannell, William, Sugiyama, Osamu, Vega, Andrew, Tang, Amy, Skorka, Tautis, Park, Sang Hyun, Oakes, Daniel, Lieberman, Jay R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813891/
https://ncbi.nlm.nih.gov/pubmed/31398502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.08.005
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