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p53 Activation by Cr(VI): A Transcriptionally Limited Response Induced by ATR Kinase in S-Phase
Cellular reduction of carcinogenic chromium(VI) causes several forms of Cr-DNA damage with different genotoxic properties. Chromate-treated cultured cells have shown a strong proapoptotic activity of the DNA damage-sensitive transcription factor p53. However, induction of p53 transcriptional targets...
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| Publicat a: | Toxicol Sci |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6813752/ https://ncbi.nlm.nih.gov/pubmed/31388677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz178 |
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