Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions

Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver. Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be al...

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Publicado en:Front Pharmacol
Main Authors: Li, Xinyi, Yu, Dongzhen, Jie, Huiqun, Zhou, Huiqun, Ye, Haibo, Ma, Guo, Wan, Lili, Li, Chunyan, Shi, Haibo, Yin, Shankai
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813656/
https://ncbi.nlm.nih.gov/pubmed/31680983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01220
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