Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions

Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver. Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be al...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Li, Xinyi, Yu, Dongzhen, Jie, Huiqun, Zhou, Huiqun, Ye, Haibo, Ma, Guo, Wan, Lili, Li, Chunyan, Shi, Haibo, Yin, Shankai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813656/
https://ncbi.nlm.nih.gov/pubmed/31680983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01220
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