A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is proposed to be near the C-terminus where multiple transmembrane domains promote hy...

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Bibliographic Details
Published in:MethodsX
Main Authors: Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan
Format: Artigo
Language:Inglês
Published: Elsevier 2019
Subjects:
Biochemistry, Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812321/
https://ncbi.nlm.nih.gov/pubmed/31667125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mex.2019.09.021
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