The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis

Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte recruitment to the gut mucosa. Leukocyte myeloperoxidase (MPO) produces the two-electron oxidant hypochlorous acid (HOCl), damaging tissue and playing a role in cellular recruitment, thereby exacerbating gut injury. W...

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Publicat a:Redox Biol
Autors principals: Chami, Belal, San Gabriel, Patrick T., Kum-Jew, Stephen, Wang, XiaoSuo, Dickerhof, Nina, Dennis, Joanne M., Witting, Paul K.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812268/
https://ncbi.nlm.nih.gov/pubmed/31593888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101333
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