The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels

BACKGROUND AND PURPOSE: The pharmacology of polyphenol metabolites on beta‐cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the insulin‐secreting function of beta‐cells and to explore the underlying mechanisms. EXPERIMENTAL APPROACH: INS‐1 beta‐cells a...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Bayle, Morgane, Neasta, Jérémie, Dall'Asta, Margherita, Gautheron, Guillaume, Virsolvy, Anne, Quignard, Jean‐François, Youl, Estelle, Magous, Richard, Guichou, Jean‐François, Crozier, Alan, Del Rio, Daniele, Cros, Gérard, Oiry, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811744/
https://ncbi.nlm.nih.gov/pubmed/31378934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14821
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