A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Zhou, Yifei, Wang, Xueqing, Song, Mengjiao, He, Zhidong, Cui, Guizhong, Peng, Guangdun, Dieterich, Christoph, Antebi, Adam, Jing, Naihe, Shen, Yidong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811558/
https://ncbi.nlm.nih.gov/pubmed/31645592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12821-2
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