Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach

The suboptimal effectiveness of β-lactam antibiotics against Mycobacterium tuberculosis has hindered the utility of this compound class for tuberculosis treatment. However, the results of treatment with a second-line regimen containing meropenem plus a β-lactamase inhibitor were found to be encourag...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Xiao, Shiqi, Guo, Haidan, Weiner, Warren S., Maddox, Clinton, Mao, Chunhong, Gunosewoyo, Hendra, Pelly, Shaaretha, White, E. Lucile, Rasmussen, Lynn, Schoenen, Frank J., Aubé, Jeffrey, Bishai, William R., Lun, Shichun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811440/
https://ncbi.nlm.nih.gov/pubmed/31427291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01319-19
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