Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

The emerging pathogenic yeast Candida auris is associated with antifungal resistance and high mortality. The novel antifungal agent manogepix (APX001A) inhibits glycosylphosphatidylinositol-anchored protein maturation and has demonstrated activity against numerous pathogenic fungi, including C. auri...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Wiederhold, Nathan P., Najvar, Laura K., Shaw, Karen J., Jaramillo, Rosie, Patterson, Hoja, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811405/
https://ncbi.nlm.nih.gov/pubmed/31427304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01120-19
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