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2590. Streptolysin O Enhances Binding of the Group A Streptococcal NAD+-Glycohydrolase Toxin to Oropharyngeal Keratinocytes

BACKGROUND: Streptolysin O (SLO) and the NAD(+)-glycohydrolase (NADase) are co-toxins secreted by group A Streptococcus (GAS) that play a significant role in virulence. NADase requires SLO for translocation into the host cell cytoplasm, a process termed cytolysin-mediated translocation (CMT). Recent...

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Bibliografiske detaljer
Udgivet i:Open Forum Infect Dis
Main Authors: Velarde, Jorge J, Lynskey, Nicola, Piai, Alessandro, Chou, James, Wessels, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811076/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2268
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