707. QPX9003: Pharmacology of a Novel Polymyxin in Mice and Rats

BACKGROUND: Currently available polymyxins are limited by toxicity and poor efficacy at tolerated doses. We have developed a new series of polymyxin derivatives with improved safety profiles and in vitro potency against major MDR bacteria. The following describes studies on the in vivo antimicrobial...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Sabet, Mojgan, Tarazi, Ziad, Parkinson, Jonathan, Roberts, Kade, Thompson, Philip, Nation, Roger, Velkov, Tony, Hecker, Scott, Lomovskaya, Olga, Dudley, Michael, Li, Jian, Grifith, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811056/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.775
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