1727. Candida albicans Phosphatidylinositol-(4,5)-Bisphosphate (PIP2) Directs Aberrant Cytokinesis and Septation in Response to Echinocandins, Which Correlates with Fungicidal Activity and Attenuated Virulence

BACKGROUND: We previously showed that highly dynamic PIP2, septin, and PKC-Mkc1 cell wall integrity pathway responses correlate with echinocandin activity against C. albicans and attenuated virulence during invasive candidiasis. Our objectives were to determine whether PIP2 dysregulation in response...

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I publikationen:Open Forum Infect Dis
Huvudupphovsmän: Badrane, Hassan, Nguyen, Minh-Hong, Clancy, Cornelius J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809340/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1590
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