1726. Candida albicans Virulence Genes Induced During Intra-abdominal Candidiasis (IAC) in the Absence of Antifungal Exposure Mediate Echinocandin Resistance

BACKGROUND: We developed and validated a mouse model of C. albicans IAC that mimics peritonitis and abscesses (IAA) in humans, and that is amenable to temporal–spatial transcriptional profiling and virulence studies. METHODS: We measured C. albicans SC5314 gene expression by RNA-Seq (RiboPure extrac...

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Bibliographic Details
Published in:Open Forum Infect Dis
Main Authors: Clancy, Cornelius J, Samanta, Palash, Cheng, Shaoji, Squires, Kevin, Nguyen, Minh-Hong
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809290/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1589
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