1556. Assessment of Translational In Vitro and Animal Pharmacokinetic–Pharmacodynamic Data Used to Support Drug Development of Recent Tetracycline Derivatives

BACKGROUND: Nonclinical (animal and in vitro) models are commonly used during the development of antibacterial drugs. Pharmacokinetic (PK) and pharmacodynamic (PD) data obtained from these nonclinical models are used to generate a PK-PD target, which can then be bridged to humans in a probability of...

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Bibliographic Details
Published in:Open Forum Infect Dis
Main Authors: Moore, Jason, Pahwa, Sonia, Yan Danielsen, Zhixia, Colangelo, Philip
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809123/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1420
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