1954. In vivo Efficacy of Delayed Therapy with the Novel Inositol Acyltransferase Inhibitor Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis

BACKGROUND: Candida auris is an emerging pathogen associated with antifungal resistance and high mortality. The novel antifungal manogepix (APX001A) prevents glycosylphosphatidylinositol-anchored protein maturation through inhibition of the inositol acyltransferase Gwt1 enzyme, and has demonstrated...

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Publié dans:Open Forum Infect Dis
Auteurs principaux: Wiederhold, Nathan P, Najvar, Laura K, Shaw, Karen J, Jaramillo, Rosie, Patterson, Hoja P, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6809074/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz359.131
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