1272. Feasibility and Successful Enrollment in Proof-of-Concept Trials to Assess Safety and Efficacy of a Broadly Neutralizing Monoclonal Antibody, VRC01, to Prevent HIV-1 Acquisitionin in Uninfected Individuals

BACKGROUND: The Antibody-mediated Prevention (AMP) trials (HVTN 704/HPTN 085 and HVTN 703/HPTN 081) are the first efficacy trials to evaluate whether VRC01, a broadly neutralizing antibody (bnAb) that targets CD4 binding site of HIV envelope, prevents HIV acquisition in uninfected individuals. In th...

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Pubblicato in:Open Forum Infect Dis
Autori principali: Edupuganti, Srilatha, Mgodi, Nyaradzo M, Karuna, Shelly, Andrew, Philip, Kochar, Nidhi, Marshall, Kyle, Decamp, Allan, Takuva, Simbarashe, Anderson, Maija, De La Grecca, Robert, Gomez Lorenzo, Margarita, Burns, David, Goepfert, Paul, McElrath, Julie, Casapia, Martin, Sanchez, Jorge, Mukwekwerere, Pamela G, Shava, Emily, Lazarus, Erica M, Hural, John, Mascola, John R, Cohen, Myron, Corey, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6808666/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1135
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