Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice

To study the effects of an analog of the gut-produced hormone peptide YY (PYY(3-36)), which has increased selectivity for the Y2 receptor; specifically, to record its effects on food intake and on hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity. NNC0165-1273, a modified...

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Pubblicato in:Endocrinology
Autori principali: Jones, Edward S, Nunn, Nicolas, Chambers, Adam P, Østergaard, Søren, Wulff, Birgitte S, Luckman, Simon M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806261/
https://ncbi.nlm.nih.gov/pubmed/31074796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00100
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