Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice

Obesity is a chronic condition resulting from a long-term pattern of poor diet and lifestyle. Long-term consumption of high-fat diet (HFD) leads to persistent activation and leptin resistance in AgRP neurons in the arcuate nucleus of the hypothalamus (ARH). Here, for the first time, we demonstrate a...

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發表在:Sci Rep
Main Authors: Wei, Wei, Pham, Kevin, Gammons, Jesse W., Sutherland, Daniel, Liu, Yanyun, Smith, Alana, Kaczorowski, Catherine C., O’Connell, Kristen M.S.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655371/
https://ncbi.nlm.nih.gov/pubmed/26592769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16810
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