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Dynamics of ABC Transporter P-glycoprotein in Three Conformational States
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational states: predominantly inward-facing apo P-gp, p...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6805939/ https://ncbi.nlm.nih.gov/pubmed/31641149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50578-2 |
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