Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

Metabolic diseases harm brain health and cognitive functions, but whether maternal metabolic unbalance may affect brain plasticity of next generations is still unclear. Here, we demonstrate that maternal high fat diet (HFD)-dependent insulin resistance multigenerationally impairs synaptic plasticity...

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Publicat a:Nat Commun
Autors principals: Fusco, Salvatore, Spinelli, Matteo, Cocco, Sara, Ripoli, Cristian, Mastrodonato, Alessia, Natale, Francesca, Rinaudo, Marco, Livrizzi, Giulia, Grassi, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805915/
https://ncbi.nlm.nih.gov/pubmed/31641124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12793-3
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