Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial

INTRODUCTION: Radiation-induced cognitive decline (RICD) is a late effect of radiotherapy (RT) occurring in 30–50% of irradiated brain tumor survivors. In preclinical models, pioglitazone prevents RICD but there are little safety data on its use in non-diabetic patients. We conducted a dose-escalati...

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書誌詳細
出版年:J Cancer Res Clin Oncol
主要な著者: Cramer, Christina K., Alphonse-Sullivan, Natalie, Isom, Scott, Metheny-Barlow, Linda J., Cummings, Tiffany L., Page, Brandi R., Brown, Doris R., Blackstock, Arthur W., Peiffer, Ann M., Strowd, Roy E., Rapp, Stephen, Lesser, Glenn J., Shaw, Edward G., Chan, Michael D.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805132/
https://ncbi.nlm.nih.gov/pubmed/30417218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-018-2791-5
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