Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial

INTRODUCTION: Radiation-induced cognitive decline (RICD) is a late effect of radiotherapy (RT) occurring in 30–50% of irradiated brain tumor survivors. In preclinical models, pioglitazone prevents RICD but there are little safety data on its use in non-diabetic patients. We conducted a dose-escalati...

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Detalhes bibliográficos
Publicado no:J Cancer Res Clin Oncol
Main Authors: Cramer, Christina K., Alphonse-Sullivan, Natalie, Isom, Scott, Metheny-Barlow, Linda J., Cummings, Tiffany L., Page, Brandi R., Brown, Doris R., Blackstock, Arthur W., Peiffer, Ann M., Strowd, Roy E., Rapp, Stephen, Lesser, Glenn J., Shaw, Edward G., Chan, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805132/
https://ncbi.nlm.nih.gov/pubmed/30417218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-018-2791-5
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