Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes

[Image: see text] The biotin–streptavidin technology has been extensively exploited to engineer artificial metalloenzymes (ArMs) that catalyze a dozen different reactions. Despite its versatility, the homotetrameric nature of streptavidin (Sav) and the noncooperative binding of biotinylated cofactor...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Wu, Shuke, Zhou, Yi, Rebelein, Johannes G., Kuhn, Miriam, Mallin, Hendrik, Zhao, Jingming, Igareta, Nico V., Ward, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805045/
https://ncbi.nlm.nih.gov/pubmed/31509711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06923
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