The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

ISG20 is a broad spectrum antiviral protein thought to directly degrade viral RNA. However, this mechanism of inhibition remains controversial. Using the Vesicular Stomatitis Virus (VSV) as a model RNA virus, we show here that ISG20 interferes with viral replication by decreasing protein synthesis i...

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Udgivet i:PLoS Pathog
Main Authors: Wu, Nannan, Nguyen, Xuan-Nhi, Wang, Li, Appourchaux, Romain, Zhang, Chengfei, Panthu, Baptiste, Gruffat, Henri, Journo, Chloé, Alais, Sandrine, Qin, Juliang, Zhang, Na, Tartour, Kevin, Catez, Frédéric, Mahieux, Renaud, Ohlmann, Theophile, Liu, Mingyao, Du, Bing, Cimarelli, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805002/
https://ncbi.nlm.nih.gov/pubmed/31600344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008093
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